Cell chemical biology, 2022-11, Vol.29 (11), p.1573-1575
2022
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Details
- Autor(en) / Beteiligte
- Titel
- A “light” touch on PI3K to interrogate cancer drug resistance
- Ist Teil von
- Cell chemical biology, 2022-11, Vol.29 (11), p.1573-1575
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In this issue of Cell Chemical Biology, Ueda et al. (2022) developed PPAP2 as an improved optogenetic tool to photo-induce PI3K signaling hyperactivation in cancer cells. They demonstrated that enhanced translation of tumor necrosis factor alpha-induced protein 8 (TNFAIP8) might explain PI3K hyperactivation-associated resistance toward DNA damaging anti-cancer alkylating agents. In this issue of Cell Chemical Biology, Ueda et al. (2022) developed PPAP2 as an improved optogenetic tool to photo-induce PI3K signaling hyperactivation in cancer cells. They demonstrated that enhanced translation of tumor necrosis factor alpha-induced protein 8 (TNFAIP8) might explain PI3K hyperactivation-associated resistance toward DNA damaging anti-cancer alkylating agents.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2451-9456eISSN: 2451-9448, 2451-9456DOI: 10.1016/j.chembiol.2022.11.005Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10353474