Details

Autor(en) / Beteiligte

• Snoek, J W
• van Weerden, T W
• Teelken, A W
• van den Burg, W
• Lakke, J P

Titel

Meige syndrome: double-blind crossover study of sodium valproate

Ist Teil von

• Journal of neurology, neurosurgery and psychiatry, 1987-11, Vol.50 (11), p.1522-1525

Ort / Verlag

London: BMJ Publishing Group Ltd

Erscheinungsjahr

1987

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• A double-blind crossover study of sodium valproate and placebo was conducted in five patients with Meige syndrome. CSF neurotransmitter studies were performed at the end of each treatment period. GABA levels were not influenced by the administration of sodium valproate. An increase in HVA levels was observed in every patient, which may reflect an increase in central dopaminergic activity. This finding may explain the trend towards clinical deterioration which was observed during treatment with sodium valproate. Sodium valproate appears to be ineffective in Meige syndrome.