Details

Autor(en) / Beteiligte

• Casal-Mouriño, Ana
• Álvarez-Dobaño, José Manuel
• Domínguez, María Jesús
• Gude, Francisco
• Toubes, María E
• Lado-Baleato, Óscar
• Martínez de Alegría, Anxo
• Taboada, Manuel
• Riveiro, Vanessa
• Rodríguez-Núñez, Nuria
• Lama, Adriana
• Ferreiro, Lucía
• Otero, Borja
• Suárez-Antelo, Juan
• Pose, Antonio
• Valdés, Luis

Titel

Development of prognostic models to estimate the probability of lung injury one year after COVID-19-related hospitalization-a prospective study

Ist Teil von

• Journal of thoracic disease, 2023-06, Vol.15 (6), p.2971-2983

Ort / Verlag

China: AME Publishing Company

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Long-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection still under study. The objectives of this study were to identify persistent pulmonary lesions 1 year after coronavirus disease 2019 (COVID-19) hospitalization and assess whether it is possible to estimate the probability that a patient develops these complications in the future. A prospective study of ≥18 years old patients hospitalized for SARS-COV-2 infection who develop persistent respiratory symptoms, lung function abnormalities or have radiological findings 6-8 weeks after hospital discharge. Logistic regression models were used to identify prognostic factors associated with a higher risk of developing respiratory problems. Models performance was assessed in terms of calibration and discrimination. A total of 233 patients [median age 66 years [interquartile range (IQR): 56, 74]; 138 (59.2%) male] were categorized into two groups based on whether they stayed in the critical care unit (79 cases) or not (154). At the end of follow-up, 179 patients (76.8%) developed persistent respiratory symptoms, and 22 patients (9.4%) showed radiological fibrotic lesions with pulmonary function abnormalities (post-COVID-19 fibrotic pulmonary lesions). Our prognostic models created to predict persistent respiratory symptoms [post-COVID-19 functional status at initial visit (the higher the score, the higher the risk), and history of bronchial asthma] and post-COVID-19 fibrotic pulmonary lesions [female; FVC% (the higher the FVC%, the lower the probability); and critical care unit stay] one year after infection showed good (AUC 0.857; 95% CI: 0.799-0.915) and excellent performance (AUC 0.901; 95% CI: 0.837-0.964), respectively. Constructed models show good performance in identifying patients at risk of developing lung injury one year after COVID-19-related hospitalization.