Details

Autor(en) / Beteiligte

• Daruwalla, Cyrus
• Shaygannejad, Vahid
• Ozakbas, Serkan
• Havrdova, Eva Kubala
• Horakova, Dana
• Alroughani, Raed
• Boz, Cavit
• Patti, Francesco
• Onofrj, Marco
• Lugaresi, Alessandra
• Eichau, Sara
• Girard, Marc
• Prat, Alexandre
• Duquette, Pierre
• Yamout, Bassem
• Khoury, Samia J
• Sajedi, Seyed Aidin
• Turkoglu, Recai
• Altintas, Ayse
• Skibina, Olga
• Buzzard, Katherine
• Grammond, Pierre
• Karabudak, Rana
• van der Walt, Anneke
• Butzkueven, Helmut
• Maimone, Davide
• Lechner-Scott, Jeannette
• Soysal, Aysun
• John, Nevin
• Prevost, Julie
• Spitaleri, Daniele
• Ramo-Tello, Cristina
• Gerlach, Oliver
• Iuliano, Gerardo
• Foschi, Matteo
• Ampapa, Radek
• van Pesch, Vincent
• Barnett, Michael
• Shalaby, Nevin
• D’hooghe, Marie
• Kuhle, Jens
• Sa, Maria Jose
• Fabis-Pedrini, Marzena
• Kermode, Allan
• Mrabet, Saloua
• Gouider, Riadh
• Hodgkinson, Suzanne
• Laureys, Guy
• Van Hijfte, Liesbeth
• Macdonell, Richard
• Oreja-Guevara, Celia
• Cristiano, Edgardo
• McCombe, Pamela
• Sanchez-Menoyo, Jose Luis
• Singhal, Bhim
• Blanco, Yolanda
• Hughes, Stella
• Garber, Justin
• Solaro, Claudio
• McGuigan, Chris
• Taylor, Bruce
• de Gans, Koen
• Habek, Mario
• Al-Asmi, Abdullah
• Mihaela, Simu
• Castillo Triviño, Tamara
• Al-Harbi, Talal
• Rojas, Juan Ignacio
• Gray, Orla
• Khurana, Dheeraj
• Van Wijmeersch, Bart
• Grigoriadis, Nikolaos
• Inshasi, Jihad
• Oh, Jiwon
• Aguera-Morales, Eduardo
• Fragoso, Yara
• Moore, Fraser
• Shaw, Cameron
• Baghbanian, Seyed Mohammad
• Shuey, Neil
• Willekens, Barbara
• Hardy, Todd A
• Decoo, Danny
• sempere, Angel Perez
• Field, Deborah
• Wynford-Thomas, Ray
• Cunniffe, Nick G
• Roos, Izanne
• Malpas, Charles B
• Coles, Alasdair J
• Kalincik, Tomas
• Brown, J William L

Titel

Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis

Ist Teil von

• Multiple sclerosis, 2023-06, Vol.29 (7), p.875-883

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background: The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear. Objective: To determine whether early non-disabling relapses predict disability accumulation in RRMS. Methods: We redefined mild relapses in MSBase as ‘non-disabling’, and moderate or severe relapses as ‘disabling’. We used mixed-effects Cox models to compare 90-day confirmed disability accumulation events in people with exclusively non-disabling relapses within 2 years of RRMS diagnosis to those with no early relapses; and any early disabling relapses. Analyses were stratified by disease-modifying therapy (DMT) efficacy during follow-up. Results: People who experienced non-disabling relapses within 2 years of RRMS diagnosis accumulated more disability than those with no early relapses if they were untreated (n = 285 vs 4717; hazard ratio (HR) = 1.29, 95% confidence interval (CI) = 1.00–1.68) or given platform DMTs (n = 1074 vs 7262; HR = 1.33, 95% CI = 1.15–1.54), but not if given high-efficacy DMTs (n = 572 vs 3534; HR = 0.90, 95% CI = 0.71–1.13) during follow-up. Differences in disability accumulation between those with early non-disabling relapses and those with early disabling relapses were not confirmed statistically. Conclusion: This study suggests that early non-disabling relapses are associated with a higher risk of disability accumulation than no early relapses in RRMS. This risk may be mitigated by high-efficacy DMTs. Therefore, non-disabling relapses should be considered when making treatment decisions.