Details

Autor(en) / Beteiligte

• Liu, Drolaiz H. W.
• Kim, Young-Woo
• Sefcovicova, Nina
• Laye, Jon P.
• Hewitt, Lindsay C.
• Irvine, Andrew F.
• Vromen, Vincent
• Janssen, Yannick
• Davarzani, Naser
• Fazzi, Gregorio E.
• Jolani, Shahab
• Melotte, Veerle
• Magee, Derek R.
• Kook, Myeong-Cherl
• Kim, Hyunki
• Langer, Rupert
• Cheong, Jae-Ho
• Grabsch, Heike I.

Titel

Tumour infiltrating lymphocytes and survival after adjuvant chemotherapy in patients with gastric cancer: post-hoc analysis of the CLASSIC trial

Ist Teil von

• British journal of cancer, 2023-06, Vol.128 (12), p.2318-2325

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2023

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Background Only a subset of gastric cancer (GC) patients with stage II–III benefits from chemotherapy after surgery. Tumour infiltrating lymphocytes per area (TIL density) has been suggested as a potential predictive biomarker of chemotherapy benefit. Methods We quantified TIL density in digital images of haematoxylin-eosin (HE) stained tissue using deep learning in 307 GC patients of the Yonsei Cancer Center (YCC) (193 surgery+adjuvant chemotherapy [S + C], 114 surgery alone [S]) and 629 CLASSIC trial GC patients (325 S + C and 304 S). The relationship between TIL density, disease-free survival (DFS) and clinicopathological variables was analysed. Results YCC S patients and CLASSIC S patients with high TIL density had longer DFS than S patients with low TIL density ( P  = 0.007 and P  = 0.013, respectively). Furthermore, CLASSIC patients with low TIL density had longer DFS if treated with S + C compared to S ( P  = 0.003). No significant relationship of TIL density with other clinicopathological variables was found. Conclusion This is the first study to suggest TIL density automatically quantified in routine HE stained tissue sections as a novel, clinically useful biomarker to identify stage II–III GC patients deriving benefit from adjuvant chemotherapy. Validation of our results in a prospective study is warranted.