Details

Autor(en) / Beteiligte

• Luterbach, Courtney L
• Chen, Liang
• Komarow, Lauren
• Ostrowsky, Belinda
• Kaye, Keith S
• Hanson, Blake
• Arias, Cesar A
• Desai, Samit
• Gallagher, Jason C
• Novick, Elizabeth
• Pagkalinawan, Stephen
• Lautenbach, Ebbing
• Wortmann, Glenn
• Kalayjian, Robert C
• Eilertson, Brandon
• Farrell, John J
• McCarty, Todd
• Hill, Carol
• Fowler, Vance G
• Kreiswirth, Barry N
• Bonomo, Robert A
• van Duin, David

Titel

Transmission of Carbapenem-Resistant Klebsiella pneumoniae in US Hospitals

Ist Teil von

• Clinical infectious diseases, 2023-01, Vol.76 (2), p.229-237

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Carbapenem-resistant Klebsiella pneumoniae (CRKp) is the most prevalent carbapenem-resistant Enterobacterales in the United States. We evaluated CRKp clustering in patients in US hospitals. From April 2016 to August 2017, 350 patients with clonal group 258 CRKp were enrolled in the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae, a prospective, multicenter, cohort study. A maximum likelihood tree was constructed using RAxML. Static clusters shared ≤21 single-nucleotide polymorphisms (SNP) and a most recent common ancestor. Dynamic clusters incorporated SNP distance, culture timing, and rates of SNP accumulation and transmission using the R program TransCluster. Most patients were admitted from home (n = 150, 43%) or long-term care facilities (n = 115, 33%). Urine (n = 149, 43%) was the most common isolation site. Overall, 55 static and 47 dynamics clusters were identified involving 210 of 350 (60%) and 194 of 350 (55%) patients, respectively. Approximately half of static clusters were identical to dynamic clusters. Static clusters consisted of 33 (60%) intrasystem and 22 (40%) intersystem clusters. Dynamic clusters consisted of 32 (68%) intrasystem and 15 (32%) intersystem clusters and had fewer SNP differences than static clusters (8 vs 9; P = .045; 95% confidence interval [CI]: -4 to 0). Dynamic intersystem clusters contained more patients than dynamic intrasystem clusters (median [interquartile range], 4 [2, 7] vs 2 [2, 2]; P = .007; 95% CI: -3 to 0). Widespread intrasystem and intersystem transmission of CRKp was identified in hospitalized US patients. Use of different methods for assessing genetic similarity resulted in only minor differences in interpretation.