Details

Autor(en) / Beteiligte

• Lee, Gahbien
• Jang, Heejin
• Oh, Yangkyun

Titel

The role of diuretic hormones (DHs) and their receptors in Drosophila

Ist Teil von

• BMB Reports, 2023-04, Vol.56 (4), p.209-215

Ort / Verlag

Korea (South): Korean Society for Biochemistry and Molecular Biology

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory inputs and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homologs of mammalian corticotropin-releasing factor (CRF) and calcitonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their receptors have multiple physiological roles, including the regulation of body-fluid secretion, sleep:wake cycle, internal nutrientsensing, and CO -dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuroendocrine systems. [BMB Reports 2023; 56(4): 209-215].