Details

Autor(en) / Beteiligte

• Armengol, Eva
• Kragh, Kasper Nørskov
• Tolker-Nielsen, Tim
• Sierra, Josep M
• Higazy, Doaa
• Ciofu, Oana
• Viñas, Miguel
• Høiby, Niels

Titel

Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

Ist Teil von

• Antimicrobial agents and chemotherapy, 2023-04, Vol.67 (4), p.e0164122-e0164122

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the need to find new strategies, such as the use of combinations of antibiotics. Among these, the combination of colistin with other antibiotics has been studied. Here, the action of combinations of colistin and rifampicin on both planktonic and sessile cells of colistin-resistant P. aeruginosa was studied. Dynamic biofilms were formed and treated with such a combination, resulting in an active killing effect of both colistin-resistant and colistin-susceptible P. aeruginosa in biofilms. The results suggest that the action of colistin on the outer membrane facilitates rifampicin penetration, regardless of the colistin-resistant phenotype. Based on these data, we propose a colistin-rifampicin combination as a promising treatment for infections caused by colistin-resistant P. aeruginosa.