Details

Autor(en) / Beteiligte

• Ranjan, Redoy
• Ken-Dror, Gie
• Martinelli, Ida
• Grandone, Elvira
• Hiltunen, Sini
• Lindgren, Erik
• Margaglione, Maurizio
• Le Cam Duchez, Veronique
• Bagan Triquenot, Aude
• Zedde, Marialuisa
• Mancuso, Michelangelo
• Ruigrok, Ynte M
• Worrall, Brad
• Majersik, Jennifer J
• Putaala, Jukka
• Haapaniemi, Elena
• Zuurbier, Susanna M
• Brouwer, Matthijs C
• Passamonti, Serena M
• Abbattista, Maria
• Bucciarelli, Paolo
• Lemmens, Robin
• Pappalardo, Emanuela
• Costa, Paolo
• Colombi, Marina
• Aguiar de Sousa, Diana
• Rodrigues, Sofia
• Canhao, Patrícia
• Tkach, Aleksander
• Santacroce, Rosa
• Favuzzi, Giovanni
• Arauz, Antonio
• Colaizzo, Donatella
• Spengos, Kostas
• Hodge, Amanda
• Ditta, Reina
• Han, Thang S
• Pezzini, Alessandro
• Coutinho, Jonathan M
• Thijs, Vincent
• Jood, Katarina
• Tatlisumak, Turgut
• Ferro, José M
• Sharma, Pankaj

Titel

Age of onset of cerebral venous thrombosis: the BEAST study

Ist Teil von

• European stroke journal, 2023-03, Vol.8 (1), p.344-350

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset. Methods: We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females. Results: A total of 1309 CVT patients (75.3% females) aged ⩾18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35–58) years and 37 (28–47) years (p < 0.001), respectively. However, the presence of antibiotic-requiring sepsis (p = 0.03, 95% CI 27–47 years) among males and gender-specific risk factors like pregnancy (p < 0.001, 95% CI 29–34 years), puerperium (p < 0.001, 95% CI 26–34 years) and oral contraceptive use (p < 0.001, 95% CI 33–36 years) were significantly associated with earlier onset of CVT among females. CFA demonstrated a significantly earlier onset of CVT in females, ~12 years younger, in those with multiple (⩾1) compared to ‘0’ risk factors (p < 0.001, 95% CI 32–35 years). Conclusions: Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (⩾1) risk factors suffer CVT ~12 years earlier compared to those with no identifiable risk factors.