Details

Autor(en) / Beteiligte

• Takahashi, Kae
• Katayama, Takayuki
• Ichikawa, Takaya
• Matsuoka, Satomi
• Kakinoki, Yasutaka
• Yoneda, Makoto
• Kimura, Akio
• Koyama, Satoshi
• Yahara, Osamu

Titel

Possible Chronic Graft-versus-host Disease in the Central Nervous System Manifesting as Cerebellar Ataxia after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

Ist Teil von

• Internal Medicine, 2023/03/01, Vol.62(5), pp.779-786

Ort / Verlag

Japan: The Japanese Society of Internal Medicine

Erscheinungsjahr

2023

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• A 44-year-old woman was admitted to our hospital with a fever, dizziness, and gait disturbance after undergoing allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia followed by graft-versus-host disease. She presented with cerebellar ataxia, nystagmus, and numbness of the lower extremities. Brain magnetic resonance imaging and perfusion scintigraphy showed progressive cerebellar involvement. Cerebrospinal fluid tests showed mildly elevated protein and IgG levels without pleocytosis. Anti-ganglioside antibodies were detected, but their levels did not follow the patient's clinical course. The patient did not respond sufficiently to steroids or other immunotherapies. We herein report the clinical characteristics of this case and a literature review.