Details

Autor(en) / Beteiligte

• Nevola, Riccardo
• Ruocco, Rachele
• Criscuolo, Livio
• Villani, Angela
• Alfano, Maria
• Beccia, Domenico
• Imbriani, Simona
• Claar, Ernesto
• Cozzolino, Domenico
• Sasso, Ferdinando Carlo
• Marrone, Aldo
• Adinolfi, Luigi Elio
• Rinaldi, Luca

Titel

Predictors of early and late hepatocellular carcinoma recurrence

Ist Teil von

• World journal of gastroenterology : WJG, 2023-02, Vol.29 (8), p.1243-1260

Ort / Verlag

United States: Baishideng Publishing Group Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Hepatocellular carcinoma (HCC) is the most frequent liver neoplasm, and its incidence rates are constantly increasing. Despite the availability of potentially curative treatments (liver transplantation, surgical resection, thermal ablation), long-term outcomes are affected by a high recurrence rate (up to 70% of cases 5 years after treatment). HCC recurrence within 2 years of treatment is defined as "early" and is generally caused by the occult intrahepatic spread of the primary neoplasm and related to the tumor burden. A recurrence that occurs after 2 years of treatment is defined as "late" and is related to de novo HCC, independent of the primary neoplasm. Early HCC recurrence has a significantly poorer prognosis and outcome than late recurrence. Different pathogenesis corresponds to different predictors of the risk of early or late recurrence. An adequate knowledge of predictive factors and recurrence risk stratification guides the therapeutic strategy and post-treatment surveillance. Patients at high risk of HCC recurrence should be referred to treatments with the lowest recurrence rate and when standardized to combined or adjuvant therapy regimens. This review aimed to expose the recurrence predictors and examine the differences between predictors of early and late recurrence.