Anticancer research, 1998-11, Vol.18 (6B), p.4713
1998
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- Autor(en) / Beteiligte
- Titel
- Prognostic significance of CYFRA 21-1 in non-small cell lung cancer
- Ist Teil von
- Anticancer research, 1998-11, Vol.18 (6B), p.4713
- Ort / Verlag
- Greece
- Erscheinungsjahr
- 1998
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Between July 1991 and February 1993, CYFRA 21-1 levels of 149 newly diagnosed patients with histologically proven non-small cell lung cancer (NSCLC) at Osaka Prefectural Habikino Hospital were measured with an enzyme immunoassay method developed by Boeringer Mannheim (Enzymun-Test CYFRA 21-1). NSCLC patients with CYFRA 21-1 serum levels over 3.5 ng/ml had a significantly poorer prognosis than did patients with normal CYFRA 21-1 levels (P < 0.001). Univariate analysis revealed that CYFRA 21-1 levels above 3.5 ng/ml, poor PS, advanced stage and serum LDH over 450 U/l strongly correlated with survival period. In multivariate analysis, however, only CYFRA 21-1 was found to be an independent prognostic factor compatible with Stage and PS (P = 0.0040 for CYFRA 21-1, P < 0.001 for PS, P = 0.0052 for Stage).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0250-7005eISSN: 1791-7530Titel-ID: cdi_pubmed_primary_9891546
- Format
- –
- Schlagworte
- Adult, Age Factors, Aged, Aged, 80 and over, Analysis of Variance, Antigens, Neoplasm - blood, Biomarkers, Tumor - blood, Carcinoma, Non-Small-Cell Lung - blood, Carcinoma, Non-Small-Cell Lung - diagnosis, Carcinoma, Non-Small-Cell Lung - mortality, Carcinoma, Non-Small-Cell Lung - therapy, Female, Follow-Up Studies, Humans, Japan, Keratin-19, Keratins, Lung Neoplasms - blood, Lung Neoplasms - diagnosis, Lung Neoplasms - mortality, Lung Neoplasms - therapy, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Prognosis, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Survival Rate, Time Factors