Details

Autor(en) / Beteiligte

• JAKUBOWSKI, M
• TRZCINKA-OCHOCKA, M
• RAINIEWSKA, G
• MATCZAK, W

Titel

Biological monitoring of occupational exposure to arsenic by determining urinary content of inorganic arsenic and its methylated metabolites

Ist Teil von

• International archives of occupational and environmental health, 1998-09, Vol.71, p.S29-S32

Ort / Verlag

Berlin: Springer

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• A study was undertaken to assess the relationship between inhalation exposure to arsenic in copper smeltery workers and urinary excretion of total inorganic arsenic metabolites (Asitm), including inorganic arsenic (Asi), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). The methods applied made it possible, in principle, to determine all forms of airborne arsenic and to eliminate the influence of seafood-derived organoarsenicals on the level of urinary Asitm. Air samples were collected on the second day of work after the weekend break. Urine samples were collected just after shift-end on the same workday. The time-weighted average (TWA) concentrations of arsenic in the workers' breathing zone varied between 1 and 746 microg/m3 and Asitm concentrations in urine between 2 and 850 microg/l (s.g. 1.024). The urine samples with a specific gravity of lower than 1.010 and higher than 1.030 were not considered; neither were those subjects with an Asitm excretion efficiency of higher than 100% of the dose absorbed during the day of measurement. In total, 53 air samples and corresponding urine samples were obtained. The correlation coefficient between the airborne arsenic concentration in microg/m3 (X) and the concentration of urinary Asitm in microg/l, s.g. 1.024 (Y), was 0.723. The relation between the two variables can be presented using the following formula: Y = 6.29 x X0.616. According to the findings of this study, as well as the results of three other studies based on similar principles, the daily exposure to arsenic concentrations of 10 microg/m3 and 50 microg/m3 led to concentrations of Asitm in urine of about 30 microg/l and 70 microg/l (s.g. 1.024), respectively.