Details

Autor(en) / Beteiligte

• McDermott, M L
• Vale, S
• Tayfour, F
• Cowden, J W

Titel

The intraocular penetration of dexamethasone after photorefractive keratectomy

Ist Teil von

• Ophthalmic surgery and lasers, 1998-10, Vol.29 (10), p.839

Ort / Verlag

United States

Erscheinungsjahr

1998

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine the effect of photorefractive keratectomy (PRK) on intraocular steroid penetration. To assess steroid penetration after PRK, four rabbits underwent unilateral myopic 9.90-D PRK procedures. The other eye was left undisturbed as a control. One week later both eyes received hourly doses of radiolabeled topical dexamethasone. No significant difference in corneal tissue [(mean +/- 1 SD) PRK 4.8 +/- 1.1 micrograms/g, control 5.2 +/- 1.2 micrograms/g] or aqueous humor concentration [(mean +/- 1 SD) PRK 0.8 +/- 0.12 microgram/ml, control 0.9 +/- 0.05 microgram/ml] of dexamethasone was seen. Dexamethasone penetration in eyes 1 week following PRK is similar to that of the unablated cornea.