Details

Autor(en) / Beteiligte

• Harry, P
• Jobard, E
• Briand, M
• Caubet, A
• Turcant, A

Titel

Ethylene glycol poisoning in a child treated with 4-methylpyrazole

Ist Teil von

• Pediatrics (Evanston), 1998-09, Vol.102 (3), p.E31-e31

Ort / Verlag

United States

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. 4-MP Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4-MP. Plasma 4-MP concentrations were in the range of the values reported to block EG metabolism. The efficiency of 4-MP treatment was confirmed by the rapid correction of metabolic acidosis without alkalization and by the increase in EG half-life. No adverse effect of 4-MP was observed. This child ingested a potentially lethal dose of EG despite a high concentration of bittering agent in antifreeze. EG poisoning was treated efficiently by 4-MP without recourse to hemodialysis.