Details

Autor(en) / Beteiligte

• Braendle, W

Titel

Hormone replacement therapy in women with breast cancer

Ist Teil von

• Anticancer research, 1998-05, Vol.18 (3C), p.2253

Ort / Verlag

Greece

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• The influence of estrogens on the growth of mammary carcinoma cell lines has been confirmed by many studies. Therefore, past or recent history of breast cancer is principally seen as a contraindication for estrogen or estrogen/progestin replacement therapy. The recently made possible early diagnosis of mammary carcinomas in many cases has resulted in a better prognosis, and means that following treatment women are living for a long time postmenopausally. Therefore, hormone replacement therapy is demanded by many patients. Recent studies with a limited number of patients, however, have shown no adverse effects of an estrogen or an estrogen-progestin replacement therapy after treatment of a mammary carcinoma. In some studies even a positive effect has been found in recurrence free survival. However, a final decision upon estrogen or estrogen/progestin replacement therapy in postmenopausal women with a history of breast cancer, cannot be made until the results of prospective clinical trials are finalized.