Details

Autor(en) / Beteiligte

• Gao, M
• Tsuchie, H
• Jin, T Q
• Zhang, J
• Detorio, M A
• Hossain, M M
• Taniguchi, K
• Kurimura, T

Titel

Difference in susceptibility to CC-chemokines among HIV-1 isolates

Ist Teil von

• International journal of STD & AIDS, 1998-08, Vol.9 (8), p.471-475

Ort / Verlag

England

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study, we examined the difference in susceptibility to anti-HIV activity of the CC-chemokines (RANTES, MIP-1 alpha and MIP-1 beta) among HIV-1 isolates and analysed its relation with phenotype (syncytium inducibility) and V3 domain of gp120 of the HIV-1 isolates. Of 11 cases tested in endogenous assay, at a concentration of 200 ng/ml, RANTES, MIP-1 alpha, and MIP-1 beta showed more than 80% suppression of HIV-1 replication in 10, 8, and 7 cases, respectively. HIV-1 isolates sensitive to more than one CC-chemokine showed non-syncytium-inducing phenotype, whereas HIV-1 isolates resistant to all of the 3 CC-chemokines showed syncytium-inducing phenotype. HIV-1 isolates resistant to all of the 3 CC-chemokines contained more positively charged amino acid residues in the V3 domain of the gp120. These results indicated that utilization of the CC-chemokine receptors as co-receptors for virus entry could vary among HIV-1 isolates.