Journal of rheumatology, 1998-06, Vol.25 (6), p.1232
1998
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Details
- Autor(en) / Beteiligte
- Titel
- Association of primary antiphospholipid syndrome with inherited activated protein C resistance
- Ist Teil von
- Journal of rheumatology, 1998-06, Vol.25 (6), p.1232
- Ort / Verlag
- Canada
- Erscheinungsjahr
- 1998
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A 65-year-old man had had arterial thromboses of the lower limbs and cerebral region for several years; tests revealed anticardiolipin, antiphosphatidylserine, anti-beta2-glycoprotein I antibodies, and lupus anticoagulant. As well, both phenotypic and genotypic resistance to activated protein C was found. Antiphospholipid antibodies have been reported to interfere in different ways with the functions of protein C; in our patient the simultaneous existence of inherited resistance to activated protein C could account for the thrombophilic status underlying the diffuse and serious arterial thromboses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0315-162XTitel-ID: cdi_pubmed_primary_9632093
- Format
- –
- Schlagworte
- Aged, Antibodies, Anticardiolipin - analysis, Antibodies, Antiphospholipid - analysis, Antiphospholipid Syndrome - blood, Antiphospholipid Syndrome - complications, Antiphospholipid Syndrome - pathology, beta 2-Glycoprotein I, Factor V - genetics, Glycoproteins - immunology, Humans, Lupus Coagulation Inhibitor - blood, Magnetic Resonance Imaging, Male, Mutation, Protein C - genetics, Thromboembolism - complications, Thromboembolism - genetics, Thromboembolism - pathology, Thrombophilia - complications, Thrombophilia - genetics, Thrombophilia - pathology