Details

Autor(en) / Beteiligte

• Chiplunkar, S V
• Deshmukh, M A
• Kode, J A
• Gangal, S G
• Deo, M G

Titel

Ability of lymphokine-activated killer cells to lyse mycobacteria-infected cells

Ist Teil von

• Acta leprologica, 1997, Vol.10 (4), p.203

Ort / Verlag

Switzerland

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• Lymphokine-activated killer (LAK) cells were generated by interleukin-2 activation of peripheral blood lymphocytes obtained from lepromatous leprosy (LL) patients and healthy individuals. The ability of LAK cells to lyse targets (macrophages and T-24, a bladder carcinoma cell line) infected with mycobacteria (Mycobacterium leprae and mycobacterial strain ICRC) was assessed in a 51 chromium-release assay. It was observed that LAK cells generated from LL patients and healthy individuals could preferentially lyse M. leprae or ICRC-pulsed macrophages and T-24 cells, compared to non-pulsed targets. The ability of LAK cells to kill intracellular mycobacteria was demonstrated in colony forming assays. These results indicate a promising role for LAK cells in immunotherapy of leprosy.