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Antioxidant nutrients: associations with persistent human papillomavirus infection
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 1997-11, Vol.6 (11), p.917
Ort / Verlag
United States: American Association for Cancer Research
Erscheinungsjahr
1997
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Research from the past several years has definitively shown intermediate and high risk-type human papillomavirus (HPV) infection
to play a significant role in cervical carcinogenesis. Persistent compared with intermittent infection appears to confer an
elevated risk, and cofactors may be necessary to allow the virus to progress to cervical cancer. We explored the association
between circulating concentrations of the antioxidant nutrients (alpha- and beta-carotene, lutein, lycopene, beta-cryptoxanthin,
alpha-tocopherol, gamma-tocopherol, and ascorbate) and persistent HPV infection among 123 low-income Hispanic women who were
all nonsmokers and were not currently using vitamin and mineral supplements. In addition, the association between these nutrients
and grade of cervical pathology, independent of HPV status, was assessed. Intermediate and high risk-type HPV infection was
assessed by the Digene Hybrid Capture System at two time points, 3 months apart. At the second interview, cytology, colposcopy,
and a fasting blood draw were conducted. Mean concentrations of serum and plasma antioxidant nutrients were calculated within
categories of HPV status (two times HPV negative, one time HPV positive, and two times HPV positive) and colposcopy. Adjusted
mean concentrations of serum beta-carotene, beta-cryptoxanthin, lutein, and alpha- and gamma-tocopherol were on average 24%
(P < 0.05) lower among women two times HPV positive compared with either two times HPV negative or one time HPV positive.
Independent of HPV status, alpha-tocopherol was significantly inversely associated with grade of cervical dysplasia (normal,
21.57 microM; cervical intraepithelial neoplasia III, 17.27 microM). The results obtained in this study need to be confirmed
in larger cohort studies with a longer follow-up period.