Details

Autor(en) / Beteiligte

• Pavlov, A Iu
• Olsuf'eva, E N
• Miroshnikova, O V
• Reznikova, M I
• Lazhko, E I
• Malabarba, A
• Ciabatti, R
• Preobrazhenskaia, M N

Titel

Non-natural aglycones of glycopeptide antibiotics of the vancomycin group. Synthesis and antibacterial activity

Ist Teil von

• Bioorganicheskaia khimiia, 1997-05, Vol.23 (5), p.410

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• A new approach for the modification of the heptapeptide core of glycopeptide antibiotics was proposed based on the replacement of amino acid residues in positions 1 and 3 in teicoplanin aglycone and in position 1 in the eremomycin aglycone. Six novel nonnatural aglycones of the vancomycin type were obtained. Compounds derived from the teicoplanin aglycone exhibited in vitro activity against Gram-positive bacteria, and two of them were also active against the vancomycin-resistant enterococci.