Details

Autor(en) / Beteiligte

• Marinho, S F
• Paciullo, V H
• Fonseca, M O
• Khoury, Z
• Yamin, M A
• Minkoves, R
• Andrade, M O
• Cavallari, M M

Titel

Persistent neutrophilic meningitis in a patient with the acquired immunodeficiency syndrome

Ist Teil von

• Revista da Sociedade Brasileira de Medicina Tropical, 1997-05, Vol.30 (3), p.241

Ort / Verlag

Brazil

Erscheinungsjahr

1997

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Persistent neutrophilic meningitis is rarely found and it is characterized by predominance of the number of neutrophils in samples of C SF (cerebrospinal fluid) from the patient after seven days of treatment. The above patient in HIV positive; he has developed fever and mental disorder for 4 months and has presented neutrophilic pleocytosis in analysis of CSF for more than 5 months. Since the beginning or the treatment he has taken antituberculous drugs and corticosteroids. For 3 months, the serologic evaluation, smears and cultures were negative. On the 60th day in hospital, the investigation of acid-fast bacilli in CSF was positive and culture confirmed the presence of Mycobacterium tuberculosis resistant to isoniazid. Several factors that may have caused this uncommon development were discussed: the disturbance of cell-mediated immunity, mainly in release of IL 8 and TNF, the simultaneous use of medicines that could alter the CSF concentration of antituberculous drugs, and the increasing number of multiresistant strains.