Details

Autor(en) / Beteiligte

• van Kooten, C
• Banchereau, J

Titel

Functional role of CD40 and its ligand

Ist Teil von

• International archives of allergy and immunology, 1997-01, Vol.113 (4), p.393-399

Ort / Verlag

Switzerland

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• CD40, a cell surface receptor which belongs to the TNF-R family, was first identified and functionally characterized on B lymphocytes. In recent years, CD40 has been found expressed on other cells, including monocytes, dendritic cells, endothelial cells and epithelial cells and is now thought to play a more general role in immune regulation. The present paper reviews recent developments about CD40, with main emphasis on: (1) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro function of CD40 on different cell types, and (4) in vivo functions of CD40/CD40L interactions.