Details

Autor(en) / Beteiligte

• Murphy, Jr, G M
• Sullivan, E V
• Gallagher-Thompson, D
• Thompson, L W
• van Duijn, C M
• Forno, L S
• Ellis, W G
• Jagust, W J
• Yesavage, J
• Tinklenberg, J R

Titel

No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease

Ist Teil von

• Neurology, 1997-05, Vol.48 (5), p.1313-1316

Ort / Verlag

United States

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• The alpha 1-antichymotrypsin (ACT) A allele was recently associated with Alzheimer's disease (AD), and the ACT AA genotype was reported to be more frequent in AD subjects with the apolipoprotein E (APOE) epsilon4 allele. We examined ACT and APOE genotypes in a sample of 160 subjects with probable AD and in 102 elderly control subjects. ACT A allele frequencies were similar in AD subjects (0.503) and elderly controls (0.519). In addition, we found no evidence that in AD the AA genotype is more frequent in subjects with the APOE epsilon4 allele than in those without it. Our results do not support an association between the ACT A allele and AD.