Advances in Research on Neurodegeneration, 1997, Vol.50, p.55-66
1997
Details
- Autor(en) / Beteiligte
- Titel
- Mechanism of 6-hydroxydopamine neurotoxicity
- Ist Teil von
- Advances in Research on Neurodegeneration, 1997, Vol.50, p.55-66
- Ort / Verlag
- Vienna: Springer Vienna
- Erscheinungsjahr
- 1997
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson’s disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity. 6-OHDA has two ways of action: it easly forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive towards radical scavengers and iron chelators with the exception of desferrioxamine. We conclude that free radicals ate not involved in the interaction between 6-OHDA and the respiratory chain and that the two mechanisms are biochemically independent, although they may act synergistically in vivo.
- Sprache
- Englisch
- Identifikatoren
- ISBN: 3211828982, 9783211828984ISSN: 0303-6995DOI: 10.1007/978-3-7091-6842-4_7Titel-ID: cdi_pubmed_primary_9120425
- Format
- –
- Schlagworte
- Animals, Brain - drug effects, Brain - metabolism, Brain - pathology, Chelating Agents - pharmacology, Dopamine Neuron, Dopaminergic Neuron, Free Radical Scavengers - pharmacology, Free Radicals, Humans, Iron Chelator, Mitochondria - drug effects, Mitochondria - metabolism, Mitochondrial Respiration, Mitochondrial Respiratory Chain Complex, Models, Neurological, Nerve Degeneration, Neurons - drug effects, Neurons - pathology, Neurons - physiology, Neurotoxins - metabolism, Neurotoxins - toxicity, Oxidative Stress, Oxidopamine - metabolism, Oxidopamine - toxicity, Oxygen Consumption - drug effects, Parkinson Disease - metabolism, Parkinson Disease - pathology