Details

Autor(en) / Beteiligte

• Vachek, J
• Gersl, V
• Fusek, J
• Krs, O
• Skopec, F
• Bajgar, J

Titel

Toxicities of O-alkyl S-(2-dialkylaminoethyl) methyl phosphonothiolates (V-compounds)

Ist Teil von

• Acta medica Lékarskí fakulty Univerzity Karlovy v Hradci Králove, 1996, Vol.39 (2), p.67

Ort / Verlag

Czech Republic

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• Toxicities expressed as LD50 values of O-alkyl S-(2-dialkylaminoethyl) methyl phosphonothiolates in different species and different routes of administration were determined. Rats were more sensitive to these compounds than mice, rabbits and guinea-pigs were more sensitive than mice and rats. The most sensitive to these compounds were dogs. LD50 values varied in a wide range, however, a decrease of toxicity was observed in the following rank: i.v., i.m., s.c., i.p., p.o. and p.c., respectively. Depending on the route of administration, LD50 values varied from 5 g/kg (i.m., dogs) through tens of microgram/kg for the most part of compounds and routes of administration to hundreds, rarely thousands of g/kg (some chemicals, p.c. administration).