Details

Autor(en) / Beteiligte

• Livraghi, T
• Goldberg, S N
• Monti, F
• Bizzini, A
• Lazzaroni, S
• Meloni, F
• Pellicanò, S
• Solbiati, L
• Gazelle, G S

Titel

Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases

Ist Teil von

• Radiology, 1997-01, Vol.202 (1), p.205-210

Ort / Verlag

United States

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• To assess the effect of intraparenchymal saline injection on the results of radio-frequency (RF) tissue ablation. Ex vivo and in vivo animal RF ablation was performed with and without intraparenchymal saline injection. Initially, saline was injected as a bolus (1-20 mL) before RF application. For subsequent in vivo studies, saline was injected as a bolus before RF application or continuously (1 mL/min) during RF application. Finally, 14 patients with liver metastases and one patient with primary cholangiocarcinoma were treated with the continuous infusion technique. A single RF electrode (tip exposure, 1-3 cm) was used with various ablation parameters. With pretreatment bolus injection of saline, lesions measured 1.4 cm +/- 0.1, 1.6 cm +/- 0.2, and 1.2 cm +/- 0.1 in ex vivo liver, in vivo animal muscle, and in vivo animal liver, respectively. Without saline enhancement, lesion sizes were 1.0 +/- 0.2, 1.2 +/- 0.2, and 0.8 +/- 0.1 cm, respectively. With continuous saline injection in in vivo pig liver, lesion size was 1.8 - 4.1 cm in diameter. In human tumors, necrosis volume was variable, but complete necrosis was seen in 13 of 25 lesions (diameter, 1.2-3.9 cm). Partial necrosis greater than 50% was seen in 12 lesions (diameter, 1.5-4.5 cm). Saline-enhanced RF ablation might permit percutaneous destruction of large liver lesions.