Details

Autor(en) / Beteiligte

• Weller, R E
• Buschbom, R L
• Dagle, G E
• Park, J F
• Ragan, H A
• Watson, C R

Titel

Hypoadrenocorticism in beagles exposed to aerosols of plutonium-238 dioxide by inhalation

Ist Teil von

• Radiation research, 1996-12, Vol.146 (6), p.688

Ort / Verlag

United States

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-particle activity. Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an autoimmune disorder linked to damage resulting from alpha-particle irradiation to the lymphatic system.