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INHIBITION OF CYTOKINE-INDUCIBLE NITRIC OXIDE SYNTHASE IN RAT MICROGLIA AND MURINE MACROPHAGES BY METHYL-2,5- DIHYDROXYCINNAMATE
Neurochemistry international, 1996-07, Vol.29 (1), p.83-87
ZIELASEK, JURGEN
MULLER, BARBARA
HARTUNG, HANS-PETER
1996
Details
Autor(en) / Beteiligte
ZIELASEK, JURGEN
MULLER, BARBARA
HARTUNG, HANS-PETER
Titel
INHIBITION OF CYTOKINE-INDUCIBLE NITRIC OXIDE SYNTHASE IN RAT MICROGLIA AND MURINE MACROPHAGES BY METHYL-2,5- DIHYDROXYCINNAMATE
Ist Teil von
Neurochemistry international, 1996-07, Vol.29 (1), p.83-87
Ort / Verlag
Oxford: Elsevier Ltd
Erscheinungsjahr
1996
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Microglial cells are resident macrophages in the central nervous system (CNS) which serve specific functions in the defence of the CNS against microorganisms, the removal of tissue debris in neurodegenerative diseases or during normal development, and in autoimmune inflammatory disorders of the brain. Microglia express a cytokine-inducible isoform of nitric oxide synthase, which leads to the production of nitric oxide (NO). Since NO is highly toxic to neurons and oligodendrocytes, we were interested to test down-regulating neuropeptides and second messenger de-activators in order to identify novel antagonists of cytokine-induced NO production. We found that only the tyrosine kinase inhibitor methyl-2,5-dihydroxycinnamate suppressed cytokine-induced NO production by rat microglial cells and murine macrophages, while a range of other tyrosine kinase inhibitors, neuropeptides and growth factors was ineffective. Since NO production may play a role in the pathogenesis of experimental neuroimmunological disorders like experimental autoimmune encephalomyelitis and experimental autoimmune neuritis, our findings suggest a possible therapeutic role for tyrosine kinase inhibitors. Copyright © 1996 Elsevier Science Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0197-0186
eISSN: 1872-9754
DOI: 10.1016/0197-0186(95)00136-0
Titel-ID: cdi_pubmed_primary_8808792
Format
–
Schlagworte
Animals
,
Animals, Newborn
,
Biological and medical sciences
,
Cell Line
,
Cinnamates - pharmacology
,
Cytokines - antagonists & inhibitors
,
Cytokines - pharmacology
,
Down-Regulation - drug effects
,
Enzyme Induction - drug effects
,
Enzyme Inhibitors - pharmacology
,
Fundamental and applied biological sciences. Psychology
,
Isolated neuron and nerve. Neuroglia
,
Macrophages - drug effects
,
Macrophages - enzymology
,
Mice
,
Microglia - drug effects
,
Microglia - enzymology
,
Nerve Growth Factors - pharmacology
,
Neuropeptides - pharmacology
,
Nitric Oxide - biosynthesis
,
Nitric Oxide - metabolism
,
Nitric Oxide Synthase - antagonists & inhibitors
,
Nitric Oxide Synthase - biosynthesis
,
Protein-Tyrosine Kinases - antagonists & inhibitors
,
Protein-Tyrosine Kinases - biosynthesis
,
Rats
,
Rats, Inbred Lew
,
Vertebrates: nervous system and sense organs
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