Details

Autor(en) / Beteiligte

• Bekman, G
• Vennberg, K
• Bekman, L
• Spitsyn, V A
• Novoradovskiĭ, A G

Titel

Polymorphism of placental alkaline phosphatase on the level of DNA and protein in the Mordovian population

Ist Teil von

• Genetika, 1996-03, Vol.32 (3), p.420

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

1996

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Data on DNA and enzyme polymorphisms of human placental alkaline phosphatase (PLAP) in Mordvinian populations are presented. Restriction fragment length polymorphism (RFLP) was detected after the digestion of DNA samples with Rsa I and Pst I endounucleases. The frequencies of the second (2) allele for PLAP Pst I and Rsa I were 0.53 and 0.192, respectively. Comparative data suggest that there are no population differences between Mordvinians and Scandinavian ethnic groups. In Mordvinians gene frequencies measured at the level of gene products were PLAP*1(S) = 0.681, PLAP*2(F) = 0.244, PLAP*3(I) = 0.069, and PLAP*18(D) = 0.006, indicating the similarity of the corresponding values in Scandinavians. The observed RFLP and "protein" genotype frequencies were in good agreement with that expected according to the Hardy-Weinberg equation. In the Mordvinian population, as in those, surveyed previously, a strong linkage disequilibrium between Pst I and Rsa I PLAP alleles was observed.