Details

Autor(en) / Beteiligte

• KELLY, P.A.
• ALI, S.
• ROZAKIS, M.
• GOUJON, L.
• NAGANO, M.
• PELLEGRINI, I.
• GOULD, D.
• DJIANE, J.
• EDERY, M.
• FINIDORI, J.
• POSTEL-VINAY, M.C.
• Bardin, C. Wayne

Titel

The Growth Hormone/Prolactin Receptor Family

Ist Teil von

• Recent Progress in Hormone Research, 1993, Vol.48, p.123-164

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1993

Quelle

MEDLINE

Beschreibungen/Notizen

• This chapter provides an overview of growth hormone (GH) and prolactin receptor (PRL) family. Sequence analysis has confirmed that GH and PRL have selected regions of strong homology and, along with placental lactogen (PL) or chorionic somatotropin (CS), form a family of polypeptide hormones that appear to have arisen by the duplication of an ancestral gene. Hormones act by first binding to a specific receptor on or inside the cell. Two general classes of hormone receptors exist, namely, DNA binding receptors and membrane receptors. The events responsible for the transfer of the hormonal message inside the cell occur just after the interaction of the ligand with the receptor; they remain, for the most part, unknown. In mammals, PRL is primarily responsible for the development of the mammary gland and lactogenesis. The best known effects of PRL are in mammary epithelial cells. PRL acts in association with insulin and glucocorticoids to stimulate milk protein gene expression at both the transcriptional and posttranscriptional levels, because the rate of gene transcription and the stability of milk protein mRNAs are increased under the influence of the hormone. GH, on the other hand, has a direct action on the differentiation of preadipocytes, where it is necessary for the initiation of the differentiation program for cells to become responsive to insulin-like growth factor-I and for its mitogenic effect.