Cancer detection and prevention, 1993, Vol.17 (2), p.289
1993
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Details
- Autor(en) / Beteiligte
- Titel
- Recombinant immunotoxins: new therapeutic agents for cancer treatment
- Ist Teil von
- Cancer detection and prevention, 1993, Vol.17 (2), p.289
- Ort / Verlag
- England
- Erscheinungsjahr
- 1993
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We have developed new agents for the treatment of cancer by genetically modifying Pseudomonas exotoxin. We have deleted the cell-binding region of Pseudomonas exotoxin and replaced it with various growth factors or the combining regions of antibodies in a single chain form. These new recombinant molecules are called recombinant toxins. Several different types of recombinant toxins have been produced. B3(Fv)-PE38KDEL is a recombinant toxin that kills many different adenocarcinomas and epidermoid carcinomas. The molecule is now undergoing preclinical development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0361-090XTitel-ID: cdi_pubmed_primary_8402714
- Format
- –
- Schlagworte
- ADP Ribose Transferases, Animals, Bacterial Toxins - genetics, Bacterial Toxins - therapeutic use, Exotoxins - genetics, Exotoxins - therapeutic use, Immunotoxins - genetics, Immunotoxins - therapeutic use, Mice, Neoplasms, Experimental - drug therapy, Neoplasms, Experimental - genetics, Pseudomonas aeruginosa Exotoxin A, Translocation, Genetic, Virulence Factors