Anti-cancer drug design, 1993-10, Vol.8 (5), p.361
1993
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Details
- Autor(en) / Beteiligte
- Titel
- The linking chain length in bridged aldehyde-substituted pyridinium dimers modulates a slow reversible binding that affects supercoiling of plasmid DNA
- Ist Teil von
- Anti-cancer drug design, 1993-10, Vol.8 (5), p.361
- Ort / Verlag
- United States
- Erscheinungsjahr
- 1993
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Bridged aldehyde substituted pyridinium dimers bind to DNA. Binding induces retardation of the electrophoretic migration of circular plasmid due to relaxation of supercoiling. Binding to DNA is slow and reversible and depends on the length of linking chain, pH, ionic strength and temperature. It is postulated that release of topological stress results from the disruption of hydrogen bonding between complementary bases, a hypothesis consistent with facilitated attack of DNA by formaldehyde promoted by the bridged compounds.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0266-9536Titel-ID: cdi_pubmed_primary_8251043
- Format
- –
- Schlagworte
- Animals, Base Sequence, Cattle, DNA - metabolism, Electrophoresis, Formaldehyde - metabolism, Molecular Sequence Data, Plasmids - metabolism, Protein Binding, Pyridinium Compounds - chemistry, Pyridinium Compounds - metabolism, Structure-Activity Relationship, Thymus Gland - chemistry