Cancer research (Chicago, Ill.), 1994-03, Vol.54 (5), p.1240-1248
1994
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Details
- Autor(en) / Beteiligte
- Titel
- Cell death induced by peroxidized low-density lipoprotein : endopepsis
- Ist Teil von
- Cancer research (Chicago, Ill.), 1994-03, Vol.54 (5), p.1240-1248
- Ort / Verlag
- Philadelphia, PA: American Association for Cancer Research
- Erscheinungsjahr
- 1994
- Quelle
- Open access e-journals list
- Beschreibungen/Notizen
- Peroxidized low-density lipoprotein (p-LDL) has been previously demonstrated to be preferentially cytotoxic to certain malignant cells compared to normal cells of the same type. We present evidence that p-LDL is at least partially taken up through the LDL receptor and that it becomes localized in lysosomes. The integrity of lysosomes of p-LDL-treated cells is compromised, and leakage of their contents into the cytosol occurs. This leakage occurs early and precedes mitochondrial dysfunction. Brefeldin A inhibits this leakage, perhaps by interfering with the traffic between endosomes and lysosomes. Electron micrographs taken at various times suggest a mechanism of cell death which resembles certain aspects of the broad definition of apoptosis. However, we suggest that the cell death observed following p-LDL-induced release of lysosomal contents is essentially unique, with released lysosomal enzymes degrading the cell from within. We suggest that this process should be described as endopepsis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0008-5472eISSN: 1538-7445Titel-ID: cdi_pubmed_primary_8118812
- Format
- –
- Schlagworte
- Adenocarcinoma - drug therapy, Adenocarcinoma - pathology, Adenocarcinoma - ultrastructure, Ageing, cell death, Antineoplastic agents, Biological and medical sciences, Brefeldin A, Cell Death - drug effects, Cell Death - physiology, Cell physiology, Cyclopentanes - pharmacology, Drug Synergism, Endopeptidases - physiology, Fibrosarcoma - drug therapy, Fibrosarcoma - pathology, Fibrosarcoma - ultrastructure, Fundamental and applied biological sciences. Psychology, General aspects, Hip - pathology, Humans, Hydrolases - secretion, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Kinetics, Lipoproteins, LDL - antagonists & inhibitors, Lipoproteins, LDL - pharmacokinetics, Lipoproteins, LDL - toxicity, Lysosomes - enzymology, Lysosomes - metabolism, Male, Medical sciences, Mitochondria - drug effects, Mitochondria - physiology, Molecular and cellular biology, Neoplasms, Experimental - drug therapy, Neoplasms, Experimental - pathology, Peroxides - toxicity, Pharmacology. Drug treatments, Prostatic Neoplasms - drug therapy, Prostatic Neoplasms - pathology, Prostatic Neoplasms - ultrastructure, Protein Synthesis Inhibitors - pharmacology, Receptors, LDL - metabolism, Tumor Cells, Cultured