Details

Autor(en) / Beteiligte

• Horejsí, V
• Cinek, T
• Angelisová, P
• Cerný, J
• Hilgert, I

Titel

Association of GPI-anchored glycoproteins with other components of the leucocyte membrane

Ist Teil von

• Brazilian journal of medical and biological research, 1994-02, Vol.27 (2), p.255

Ort / Verlag

Brazil

Erscheinungsjahr

1994

Quelle

MEDLINE

Beschreibungen/Notizen

• The leucocyte surface glycosylphosphatidylinositol (GPI)-anchored membrane proteins are localized within specific membrane microdomains which also contain specific (glyco)lipids and intracellular proteins including protein kinases. These "GPI-domains" are devoid of most abundant transmembrane proteins, but in T-cells they appear to contain small amounts of CD4 and CD8 and in B-cell lines, small amounts of CD10. The existence of these relatively detergent-resistant membrane microdomains explains the signal-transducing ability of GPI-anchored receptors. In addition to the "GPI-microdomains", several other types of analogous very large detergent-resistant complexes/domains appear to exist, such as those containing T-cell receptor, others containing CD45R molecules associated with a protein kinase, and still others composed mainly of several proteins of the tetraspan family. Therefore, we suggest that the leucocyte surface is a mosaic of microdomains of unique composition associated with specific signal-transducing molecules.