Details

Autor(en) / Beteiligte

• Katholi, R E
• Taylor, G J
• McCann, W P
• Woods, Jr, W T
• Womack, K A
• McCoy, C D
• Katholi, C R
• Moses, H W
• Mishkel, G J
• Lucore, C L

Titel

Nephrotoxicity from contrast media: attenuation with theophylline

Ist Teil von

• Radiology, 1995-04, Vol.195 (1), p.17-22

Ort / Verlag

United States

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine if depression of creatinine clearance after administration of contrast medium may be prevented with theophylline. A nonionic, low-osmolality contrast medium (iopamidol) or an ionic, high-osmolality contrast medium (sodium diatrizoate) was administered to 93 patients. Before the examination, these patients were given theophylline or a placebo orally. There were also 30 patients who received an adenosine-uptake inhibitor (dipyridamole). Creatinine clearance and urinary adenosine levels were measured before and after angiography. Creatinine clearance decreased 18% +/- 4 in the placebo-iopamidol group but did not decrease in the theophylline group; urinary adenosine increased 67% +/- 7. Creatinine clearance decreased 42% +/- 5 in the placebo-sodium diatrizoate group and decreased 24% +/- 3 in the theophylline group; urinary adenosine increased 119% +/- 8. In the dipyridamole group in which iopamidol was given, urinary adenosine increased 96% +/- 7 and creatinine clearance decreased 37% +/- 5. Intrarenal adenosine can be implicated in the pathogenesis of hypertonic contrast medium nephrotoxicity.