Details

Autor(en) / Beteiligte

• Galleni, M.
• Raquet, X.
• Lamotte-Brasseur, J.
• Fonzé, E.
• Amicosante, G.
• Frère, J.M.

Titel

DD-Peptidases and β-Lactamases: Catalytic Mechanisms and Specificities

Ist Teil von

• Journal of chemotherapy, 1995-02, Vol.7 (1), p.3-7

Ort / Verlag

Firenze: Taylor & Francis

Erscheinungsjahr

1995

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• DD-peptidases and β-lactamases share several common properties, including the formation of an acylen-zyme intermediate in their catalytic pathways. In their interactions with β-lactam antibiotics, the stability of this intermediate is much higher with the peptidases than with the β-lactamases. The structural factors responsible for this difference have not been identified. The evolution of β-lactamases is taking place before our eyes, since mutants are constantly selected which can hydrolyze the molecules newly introduced as "β-lacta-mase resistant" in the chemotherapeutic arsenal.