Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Possible implications for radiotherapy
Ist Teil von
Radiology, 1982-01, Vol.142 (1), p.225
Ort / Verlag
United States
Erscheinungsjahr
1982
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Studies performed on a human melanoma line in exponential growth showed radiation survival parameters similar to those of other tumors (n = 1.2, D0 = 151). In plateau-phase cultures, however, this tumor cell line was efficient in the repair of potentially lethal radiation damage, especially when large dose fractions were employed (there was a 48-fold recovery after 1,200 rad [12 Gy]). Thus, extrapolation from survival data generated only on exponentially growing cells may be misleading when determining the ultimate surviving fraction in some tumors. Large-fraction radiotherapy may not be effective in tumors that contain cells analogous to plateau-phase cells.