Details

Autor(en) / Beteiligte

• Butler, Merlin G.
• Walzak, Myron P.
• Sanger, Warren G.
• Todd, Curtis T.

Titel

A Possible Etiology of the Infertile 46XX Male Subject

Ist Teil von

• The Journal of urology, 1983-07, Vol.130 (1), p.154-156

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1983

Quelle

MEDLINE

Beschreibungen/Notizen

• We report on an infertile male patient with the predominant 46XX female karyotype. A testicular biopsy revealed widely separated testicular tubules, absence of sperm formation and large numbers of Leydig cells. Chromosome studies, including measurements of the X chromosomes, showed a significant difference between the lengths of the short arm of the 2 X chromosomes. This information lends support for an X-Y chromosome interchange as the etiology of this syndrome. The clinical features of this rare syndrome and other theories of etiology of XX male subjects are discussed.