Details

Autor(en) / Beteiligte

• Bradley, D W
• Maynard, J E
• Popper, H
• Ebert, J W
• Cook, E H
• Fields, H A
• Kemler, B J

Titel

Persistent non-A, non-B hepatitis in experimentally infected chimpanzees

Ist Teil von

• The Journal of infectious diseases, 1981-02, Vol.143 (2), p.210-218

Ort / Verlag

United States

Erscheinungsjahr

1981

Quelle

MEDLINE

Beschreibungen/Notizen

• Non-A, non-B (NANB) hepatitis was transmitted to six chimpanzees by intravenous inoculation of antihemophilic (factor VIII) materials, acute-phase chimpanzee liver, and chronic-phase plasma obtained from two NANB hepatitis-infected chimpanzees 10 and 16 months, respectively, after their inoculation. Five of six experimentally infected chimpanzees observed for more than one year demonstrated persistent or intermittent elevations in levels of serum alanine aminotransferase (ALT) indicative of continuing liver dysfunction. Liver biopsy specimens obtained from three chimpanzees with persistent elevations in levels of ALT were positive for hepatocyte cytoplasmic structures associated with NANB hepatitis for as long as 27 months after inoculation. Liver biopsy specimens obtained from four infected animals 13-30 months after inoculation also showed mild but persistent histopathologic lesions of undefined character. The detection of circulating immune complexes in one chimpanzee with persistent elevations in levels of ALT suggests that these complexes may be involved in the pathogenesis of NANB hepatitis.