Journal of endocrinology, 1984-04, Vol.101 (1), p.107-111
1984
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Details
- Autor(en) / Beteiligte
- Titel
- Control of thyroglobulin secretion from the rat thyroid gland
- Ist Teil von
- Journal of endocrinology, 1984-04, Vol.101 (1), p.107-111
- Ort / Verlag
- England
- Erscheinungsjahr
- 1984
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Thyroid-stimulating hormone (TSH) stimulated Tg release in vitro from enzymatically dispersed normal rat thyroid cells in a dose-dependent manner. Thyroid cells prepared from T4-treated animals behaved similarly to cells from control rats, whereas in vitro basal release of Tg from thyroid cells prepared from PTU-treated animals was high and the response to TSH was lost. Our data confirm the TSH dependency of Tg release in vivo and in vitro and our system provides a means of studying the control of Tg secretion in vitro.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-0795eISSN: 1479-6805DOI: 10.1677/joe.0.1010107Titel-ID: cdi_pubmed_primary_6707550
- Format
- –
- Schlagworte
- Animals, Dose-Response Relationship, Drug, Female, In Vitro Techniques, Propylthiouracil - pharmacology, Radioimmunoassay, Rats, Rats, Inbred Strains, Thyroglobulin - blood, Thyroglobulin - metabolism, Thyroid Gland - drug effects, Thyroid Gland - metabolism, Thyrotropin - pharmacology, Thyroxine - pharmacology