Details

Autor(en) / Beteiligte

• Zmijewski, Chester M.
• Fuller, Thomas C.

Titel

HLA and Disease

Ist Teil von

• CRC critical reviews in clinical laboratory sciences, 1984, Vol.20 (4), p.285-370

Ort / Verlag

Cleveland, OH: Informa UK Ltd

Erscheinungsjahr

1984

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• This review describes the greater portion of a large number of new studies on HLA and disease association which has appeared in the literature since 1979. The majority of these are concerned with the association of certain diseases with class II major histocompatibility complex antigens. The possible biologic significance of these associations in terms of their probable etiology appears to be the prevailing theme. Current thinking regarding certain heritable diseases is described. It seems that although much has been done to resolve the genetics of insulin-dependent diabetes mellitus, other diseases such a multiple sclerosis still remain a mystery. Doubtlessly, much will be gained from DNA cloning and sequencing studies proposed for the future. A great deal of new information has been obtained relative to HLA itself. New loci have been postulated in the HLA-D/DR region through the use of powerful immunochemical procedures made possibly by the advent of modern technological advances. The impact of these developments on our understanding of the function of the MHC in man and its possible relationship to disease are discussed.