Details

Autor(en) / Beteiligte

• MIETTINEN, TATU A.

Titel

Effects of Hypolipidemic Drugs on Bile Acid Metabolism in Man

Ist Teil von

• Advances in Lipid Research, 1981, Vol.18, p.65,69a,69b,70,81a,81b,82-69,69a,69b,81,81a,81b,97

Ort / Verlag

United States: Elsevier Science & Technology

Erscheinungsjahr

1981

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• This chapter discusses the effects of hypolipidemic drugs on bile acid metabolism in man. Hypolipidemic drugs can be classified as either absorbable or unabsorbable. These latter compounds pass through the intestinal tract more or less unchanged and interfere with the absorption of either bile acids or cholesterol. The exact mechansim of the hypolipidemic action of absorbable agents, for example, clofibrate, nicotinic acid, thyroid hormones, and probucol, is less clear than that of unabsorbable drugs. Some of them apparently inhibit hepatic triglyceride and/or very-low-density lipoprotein synthesis and/or release, while others may stimulate removal of lipoproteins from the blood or interfere directly with cholesterol synthesis. The modified lipoprotein metabolism can be associated with changes in synthesis and turnover of cholesterol and subsequently with a modified bile acid metabolism. The chapter highlights the significance of modified lipoprotein and cholesterol metabolisms caused by the action of absorbable hypolipidemic agents on bile acids and the effect of enhanced bile acid metabolism caused by unabsorbable drugs on lipoprotein and cholesterol metabolism.