Details

Autor(en) / Beteiligte

• Bédi, J
• Blaskó, G
• Pálos, L A

Titel

The effect of some pyrimido-pyrimidine derivatives on blood coagulation and platelet aggregation

Ist Teil von

• Arzneimittel-Forschung, 1979, Vol.29 (9), p.1405

Ort / Verlag

Germany

Erscheinungsjahr

1979

Quelle

MEDLINE

Beschreibungen/Notizen

• Two pyrimido-pyrimidine derivatives, Chinoin 105 and Chinoin 123, respectively, were investigated with respect to the inhibition potency on platelet aggregation. It was shown that Chinoin 105 is a powerful inhibitor of aggregation of thrombocytes without effect on routine coagulation parameters in vitro. Chinoin 123 has a moderately inhibitory effect on the investigated reactions. An additive effect of Chinoin 105 to the inhibitory potential of PGE1 on platelet aggregation was proven.