Il Farmaco; edizione scientifica, 1979-10, Vol.34 (10), p.914
1979
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Research on agents with antineoplastic activity. LXIII. Anthramycin and analogous compounds. X. Synthesis of 11-phenyl-5H-pyrrolo[2,1-c[1,4benzodiazepine derivatives
- Ist Teil von
- Il Farmaco; edizione scientifica, 1979-10, Vol.34 (10), p.914
- Ort / Verlag
- Italy
- Erscheinungsjahr
- 1979
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Reaction between arolychlorides and 1-(2-aminobenzyl)-2-cyanopyrrole afforded the corresponding aroylamides, which were transformed by intramolecular cyclization into 11-aryl-3-cyano-5H-pyrrolo[2,1-c] [1,4] benzodiazepines. Hydrolysis of cyanoderivatives furnished the corresponding amides or acids depending on the reaction conditions. Decarboxylation and reduction of some derivatives to afford 11-aryl-5H-pyrrolo[2,1-c] [1,4] benzodiazepines and 11-aryl-3-cyano-10,11-dihydro-5H-pyrrolo[2,1-c] [1,4] benzodiazepines are described.
- Sprache
- Italienisch
- Identifikatoren
- ISSN: 0430-0920Titel-ID: cdi_pubmed_primary_510534
- Format
- –
- Schlagworte
- Anthramycin - analogs & derivatives, Anthramycin - chemical synthesis, Antineoplastic Agents - chemical synthesis, Benzodiazepines - chemical synthesis, Benzodiazepinones - analogs & derivatives, Cyclization, Hydrolysis, Indicators and Reagents, Oxidation-Reduction, Pyrroles - chemical synthesis