Details

Autor(en) / Beteiligte

• Colmerauer, M E
• Rumi, L
• Saal, F
• Pasqualini, C D
• Rabasa, S L

Titel

RNA-mediated immunologic depression

Ist Teil von

• The Journal of immunology (1950), 1973-09, Vol.111 (3), p.743-749

Ort / Verlag

United States

Erscheinungsjahr

1973

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract RNA extracted from normal liver had a specific immunodepressive effect in syngeneic BALB mice when administered 1 or 5 days before the antigen, as demonstrated in three different systems: 1) syngeneic leukemic colonization was accelerated and death anticipated; 2) spleen lymphocytes cultured in vivo within Millipore chambers showed a lower rate of spontaneous blastogenesis and lack of response to phytohemagglutinin; 3) after immunization with sheep red blood cells, spleen lymphocytes had a decreased rosette-forming capacity and the titer of hemagglutinins in serum was lower. It can be concluded that RNA pretreatment affects both cellular and humoral components of the immunologic system; the effect would be exerted on macrophages and/or lymphocytes.