Details

Autor(en) / Beteiligte

• Coleoni, A H
• Masini, A M

Titel

Effect of para-chlorophenylalanine on rat thyroid function

Ist Teil von

• Acta endocrinologica (Copenhagen), 1974-04, Vol.75 (4), p.717-724

Ort / Verlag

Denmark

Erscheinungsjahr

1974

Quelle

MEDLINE

Beschreibungen/Notizen

• ABSTRACT Administration of p-chlorophenylalanine (p-CPA), a brain serotonin (5-HT) depleting agent, induced a significant reduction in thyroid function as evaluated by the thyroid/serum ratio, 24 hour 131 I uptake uptake and the 131 I biological half-life. The iodo-amino acid composition of hydrolyzed thyroid tissue remained unchanged by the drug. The injection of thyrotrophin (TSH) to rats the endogenous TSH of which had previously been blocked with thyroxine, raised the plasma 131 I and PB 131 I levels in both treated and control rats. The brain 5-HT concentration measured 24 hours following the last dose of p-CPA was markedly lowered by 50 mg/kg/day and 100 mg/kg/day. Cardiac 5-HT stores were only slightly depleted, while the thyroid 5-HT content remained unchanged. These results suggest a role of brain 5-HT depletion on the reduction of thyroid function caused by p-CPA. Some possible mechanisms are briefly discussed.