Details

Autor(en) / Beteiligte

• Koke, J R
• Werchan, P M
• Sami, H
• Bittar, N

Titel

Changes in morphology of endocytotic vesicles in cardiac capillary endothelial cells and myocytes of rats after treatment with adenine and AMP

Ist Teil von

• Cytobios, 1985, Vol.42 (166), p.81

Ort / Verlag

England

Erscheinungsjahr

1985

Quelle

MEDLINE

Beschreibungen/Notizen

• Isolated rat hearts were perfused with media containing no additions (sham), adenine, or AMP to determine if adenine or AMP would affect post-ischaemic myocyte ultrastructure. The most significant change induced by both adenine and AMP was a dramatic increase in the number and size of endocytotic vesicles apparent in capillary endothelia and myocytes. This observation suggests endocytosis as a possible transport mechanism for AMP or adenine, or other large polar molecules including purine nucleotide precursors, from the coronary circulation across capillary endothelia and into myocytes.