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Splenic red cell sequestration and blood volume measurements in conscious pigs
Ist Teil von
American journal of physiology. Regulatory, integrative and comparative physiology, 1985-03, Vol.248 (3), p.293-R301
Ort / Verlag
United States
Erscheinungsjahr
1985
Quelle
MEDLINE
Beschreibungen/Notizen
J. P. Hannon, C. A. Bossone and W. G. Rodkey
When estimated by the dilution of 51Cr-labeled red blood cells under nearly
basal conditions, immature splenectomized pigs (n = 20) had a circulating
red cell volume of 17.8 +/- 1.64 (SD) ml/kg. At an assumed body-to-large
vessel hematocrit (BH:LH) ratio of 0.9, plasma volume was 49.6 +/- 3.12
ml/kg and blood volume 67.3 +/- 3.67 ml/kg. Sham-operated pigs (n = 20) had
a circulating red cell volume of 16.2 +/- 1.39 ml/kg, a plasma volume of
51.1 +/- 3.42 ml/kg, and blood volume of 67.2 +/- 4.12 ml/kg. Kinetic
analysis of early 51Cr loss from the circulating blood of the sham-operated
pigs indicated a splenic red cell sequestration of 4.5 +/- 0.89 ml/kg and a
t1/2 of 9.76 +/- 1.93 min for splenic red cell turnover. Epinephrine
injection (n = 6) and physical restraint (n = 8) caused rapid mobilization
of splenic red blood cells in sham-operated pigs. Volume estimates in
splenectomized pigs (n = 7) based on simultaneous dilutions of 51Cr-labeled
red blood cells and 125I-labeled bovine albumin gave circulating red cell,
plasma, and blood volumes of 18.4 +/- 2.46, 60.7 +/- 4.01, and 79.0 +/-
3.51 ml/kg, respectively, and a BH:LH ratio of 0.756 +/- 0.029. The latter
value may have reflected an overestimation of plasma volume by the
125I-labeled albumin procedure.