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American journal of physiology: endocrinology and metabolism, 1985-02, Vol.248 (2), p.E182-E187
Ort / Verlag
Legacy CDMS
Erscheinungsjahr
1985
Quelle
MEDLINE
Beschreibungen/Notizen
R. Brommage and H. F. DeLuca
The effects of varying dietary calcium and phosphorus content, vitamin D
deficiency, oophorectomy, adrenalectomy, and simultaneous pregnancy on bone
mineral loss during lactation were examined in rats. Unless otherwise
stated, the diet contained 0.47% calcium and 0.3% phosphorus and the rats
were given 26 nmol of vitamin D3. Femur ash weights were determined after
21 days of lactation and on age-matched nonlactating rats. Decreasing
dietary calcium to 0.02% caused an increased loss of bone mineral, whereas
increasing dietary calcium to 1.4% increased plasma calcium levels to 12
mg/100 ml but did not diminish the bone mineral loss observed during
lactation. Varying dietary phosphorus did not have a major effect on bone
mineral loss during lactation. In vitamin D-deficient rats, bone mineral
loss during lactation was independent of dietary calcium levels and
slightly greater than the loss observed in vitamin D-replete rats fed the
normal calcium diet. Oophorectomy and adrenalectomy did not produce changes
in femur ash weights of nonlactating rats or reduce bone mineral loss
during lactation. Rats mated during their postpartum estrus and thus
simultaneously pregnant and lactating, lost the same amount of bone mineral
as caused by lactation alone.